Osteonecrosis of the jaw is a rare but serious complication of bisphosphonate therapy. This can occur at a site of a previous tooth extraction or spontaneously at a nontraumatized site. It more commonly occurs with cancer patients and with IV preparations of bisphosphonates, but can occur with oral preparations as well. Head and neck radiation also increases the risk of jaw osteonecrosis.
Peker I, Alkurt MT, Usalan G. Clinical evaluation of medication on oral and dental health. Int Dent Journal. 2008; 58: 218-222.
Pazianas M, Miller P, Blumentals WA, et al. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. 2007; 29(8):1548-58.
Khan, A. Bisphosphonate associated osteonecrosis of the jaw. Can Fam Physician. 2008; 54(7): 1019-1021.
Ottesen, Camilla, Morten Schiodt, and Klaus Gotfredsen. "Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review." Heliyon 6.4 (2020): e03795.