Inflammation constitutes a major mechanism for the observed link between oral disease, specifically periodontitis, and systemic diseases, although direct cause-and-effect is difficult to establish.
There is a strong association between periodontal disease and diabetes.
Emerging evidence for links with other conditions including:
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Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, Patel VA, Boyers D, Twigg J. Treatment of periodontitis for glycaemic control in people with diabetes mellitus. Cochrane Database of Systematic Reviews 2022, Issue 4.
National Institutes of Health. Oral Health in America: Advances and Challenges. US Department of Health and  Human Services, National Institutes of Health, National Institute of Dental and Craniofacial Research; 2021.