Silver Diamine Fluoride

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Approval and Use

Silver Diamine Fluoride Silver Diamine Fluoride – Mechanism of Action and Evidence for Effectiveness Approval and Use

Silver Diamine Fluoride has been used safely for years

  • Approved by the FDA in 2014 to treat tooth hypersensitivity
  • Currently approved for caries treatment in Canada and other countries
  • Off label use for caries treatment in the United States
  • Designated Breakthrough Therapy by FDA & currently in Phase III trials to become the first drug approved for caries treatment
  • Recommended by the American Dental Association: "Clinicians are encouraged to prioritize use of these interventions based on effectiveness, safety, and feasibility."
  • Included on the WHO Lists of Essential Medicines (2021)

References:

ADA. (2023, September 19). Silver Diamine Fluoride. https://www.ada.org/resources/ada-library/oral-health-topics/silver-diamine-fluoride

Farmer, J. W., et al. (2018). Effectiveness, safety, and acceptance of silver diamine fluoride therapy and its implications for dental hygiene practice: Position paper and statement from the Canadian Dental Hygienists Association. Can J Dent Hyg 2018; 52(3): 192-207.

Cooper, L. H., Slashcheva, L., & Tomar, S. (2017). Silver Diamine Fluoride (SDF) Fact Sheet. ASTDD. https://www.astdd.org/docs/SDF-fact-sheet-upd-oct_23.pdf

Web Annex A. World Health Organization Model List of Essential Medicines - 22nd List, 2021.  Geneva: World Health Organization; 2021 (WHO/MHP/HPS/EML/2021.02). Licence: CC BY-NC-SA 3.0 IGO.

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